Lymphocyte infiltration in the injured brain: role of proinflammatory cytokines.

@article{Raivich2003LymphocyteII,
  title={Lymphocyte infiltration in the injured brain: role of proinflammatory cytokines.},
  author={Gennadij Raivich and Marion Bohatschek and Alexander Werner and Leonard L. Jones and Matthias Galiano and Christian U A Kloss and Xing-zu Zhu and Klaus Pfeffer and Zhi Qiang Liu},
  journal={Journal of neuroscience research},
  year={2003},
  volume={72 6},
  pages={726-33}
}
Studies using mouse axotomised facial motoneuron model show a strong and highly selective entry of CD3+ lymphocytes into the affected nucleus, with a maximum at Day 14, which coincides with the peak of neuronal cell death, microglial phagocytosis, and increased synthesis of interleukin-1 beta (IL1beta), tumour necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma). We explored the possible involvement of these cytokines during the main phase of lymphocyte recruitment into the… CONTINUE READING
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