Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction

  title={Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction},
  author={Younan A. Sidky and Robert D. Auerbach},
  journal={The Journal of Experimental Medicine},
  pages={1084 - 1100}
A new and sensitive assay for the effect of intracutanous administration of immunocompentent lymphocytes into the skin of irradiated unimmunized mice is described. The assay, which we have termed lymphocyte-induced angiogenesis (LIA) involves enumeration of new vascular branches induced by the action of these competent cells. As is the case for the previously described normal lymphocyte transfer reaction, LIA is a manifestation of the graft-vs.-host reaction, as shown by experiments utilizing… CONTINUE READING


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