Lymphocyte glutathione levels in children with cystic fibrosis.

  title={Lymphocyte glutathione levels in children with cystic fibrosis.},
  author={Larry C. Lands and Vijaylaxmi Grey and Argyrios A Smountas and Victor G. Kramer and D J McKenna},
  volume={116 1},
OBJECTIVE Lung disease in cystic fibrosis (CF) is characterized by a neutrophilic inflammatory response. This can lead to the production of oxidants, and to oxidative stress in the lungs. Glutathione (GSH) represents the primary intracellular antioxidant, and provides an important defense in the epithelial lining fluid. Evidence suggests that lymphocyte GSH reflects lung GSH concentrations, and so could potentially serve as a peripheral marker of lung inflammation. METHODS We assessed… CONTINUE READING