Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD

@article{Mati2013LymphocyteGR,
  title={Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD},
  author={G. Mati{\'c} and D. Milutinovi{\'c} and J. Nestorov and I. Elakovi{\'c} and D. Savi{\'c}},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2013},
  volume={43},
  pages={238-245}
}
  • G. Matić, D. Milutinović, +2 authors D. Savić
  • Published 2013
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • OBJECTIVE Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n=85), and war trauma-exposed individuals with current PTSD (n=113), with life-time PTSD (n=61) and without PTSD (trauma controls; n=88). The aim of the study was to distinguish the receptor… CONTINUE READING
    37 Citations

    Figures, Tables, and Topics from this paper.

    References

    SHOWING 1-10 OF 71 REFERENCES
    Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder
    • 96
    • Highly Influential
    • PDF
    Glucocorticoid receptor polymorphisms and post-traumatic stress disorder
    • 140
    • PDF
    Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks
    • 247
    • PDF
    Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder.
    • 232
    Cortisol production rate in posttraumatic stress disorder.
    • 34
    • Highly Influential
    • PDF
    Validation of endogenous controls for gene expression studies in peripheral lymphocytes from war veterans with and without PTSD
    • 9
    Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
    • 367
    • Highly Influential