Lymphocyte function-associated antigen-1 blockade by statins: molecular basis and biological relevance.

@article{WeitzSchmidt2003LymphocyteFA,
  title={Lymphocyte function-associated antigen-1 blockade by statins: molecular basis and biological relevance.},
  author={Gabriele Weitz-Schmidt},
  journal={Endothelium : journal of endothelial cell research},
  year={2003},
  volume={10 1},
  pages={
          43-7
        }
}
Lymphocyte function-associated antigen-1 (LFA-1) belongs to the integrin family and plays an important role in leukocyte trafficking and in T-cell activation. Random screening of chemical libraries identified the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin as an inhibitor of the LFA-1/intercellular adhesion molecule (ICAM)-1 interaction. The effect of lovastatin on LFA-1 was found to be unrelated to the inhibition of HMG-CoA reductase and to be mediated by… CONTINUE READING
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