Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance.

@article{Montserrat1986LymphocyteDT,
  title={Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance.},
  author={Emili Montserrat and J Sanchez-Bisono and N{\'u}ria Vi{\~n}olas and Ciril Rozman},
  journal={British journal of haematology},
  year={1986},
  volume={62 3},
  pages={567-75}
}
In 100 untreated patients with chronic lymphocytic leukaemia (CLL) lymphocyte doubling time (LDT) has been investigated in relationship with clinical stages, bone marrow histological patterns, treatment-free period and survival. Although partially correlated with clinical stages and bone marrow patterns, LDT has a clear prognostic significance by itself: whereas a LDT of 12 or less months identifies a population of patients with poor prognosis, a LDT higher than 12 months is indicative of good… CONTINUE READING

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