Lymphocyte development: Signalling identity

@article{Minami2005LymphocyteDS,
  title={Lymphocyte development: Signalling identity},
  author={Keita Minami and Yoshiki Yanagawa and Kazuya Iwabuchi and Nobuo Shinohara and Toru Harabayashi and Katsuya Nonomura and Kazunori On{\'o}e},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={519-519}
}
The ability of extracellular stimuli to modulate dendritic cell (DC) activation of natural killer T (NKT) cells was not well understood. We investigated the effects of the T helper type 1 (Th1)/Th2-cytokine environment on DC induction of NKT cell-mediated cytokine production in mice. Pretreatment of myeloid DCs with Th1 or Th2 cytokines, interleukin (IL)-4 or interferon (IFN)-gamma, led to the enhanced production of reciprocal cytokines by NKT cells (eg, IL-4 pretreatment led to the enhanced… CONTINUE READING
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