Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

@article{Shamri2005LymphocyteAR,
  title={Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines},
  author={Revital Shamri and Valentin Grabovsky and Jean-Marc M Gauguet and Sara W. Feigelson and Eugenia Manevich and Waldemar Kolanus and Martyn K. Robinson and Donald E. Staunton and Ulrich H. von Andrian and Ronen Alon},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={497-506}
}
It is widely believed that rolling lymphocytes require successive chemokine-induced signaling for lymphocyte function–associated antigen 1 (LFA-1) to achieve a threshold avidity that will mediate lymphocyte arrest. Using an in vivo model of lymphocyte arrest, we show here that LFA-1-mediated arrest of lymphocytes rolling on high endothelial venules bearing LFA-1 ligands and chemokines was abrupt. In vitro flow chamber models showed that endothelium-presented but not soluble chemokines triggered… CONTINUE READING
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