Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

@article{Vivier2002LymphocyteAV,
  title={Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?},
  author={Eric Vivier and Elena Tomasello and P Emmanuel Vijay Paul},
  journal={Current opinion in immunology},
  year={2002},
  volume={14 3},
  pages={
          306-11
        }
}
NKG2D is an activating cell surface receptor expressed on a wide range of immune effector cells including NK cells, NKT cells, gammadelta T cells as well as CD8(+) alphabeta T cells. Recent data indicate two major features: first, that human (MICA, MICB and ULBP) and mouse (Rae1 and H60) NKG2D ligands can be induced and/or upregulated upon cellular distress; and second, that on T cells NKG2D serves as a co-stimulation molecule for TCR triggering, whereas on NK cells NKG2D may act as a primary… CONTINUE READING
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