Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells.

@article{Borthwick1994LymphocyteAI,
  title={Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells.},
  author={Nicola J. Borthwick and Margarita Bofill and Wendy M. Gombert and Arne N. Akbar and Enrique Medina and Katsuhiko Sagawa and Marc Caeroos Isaac Lipman and Margaret A T Johnson and George Janossy},
  journal={AIDS},
  year={1994},
  volume={8 4},
  pages={431-41}
}
OBJECTIVES AND DESIGN The expression of the accessory molecule CD28 was compared in various populations of T and natural killer (NK) cells from HIV-1-negative and HIV-1-positive individuals and correlated with activation using mitogens in vitro. METHODS Multiparameter flow cytometric analysis using combinations of CD3 CD28 and other markers was performed together with absolute cell counting in peripheral blood. Blast transformation and proliferative responses were also quantitated using the… CONTINUE READING
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