Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

@article{Kunkel2000LymphocyteCC,
  title={Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment},
  author={Eric J. Kunkel and James J Campbell and Guttorm Haraldsen and Junliang Pan and Judie Boisvert and Arthur I. Roberts and Ellen Catherine Ebert and Mark A. Vierra and Stuart B Goodman and Mark C Genovese and Andrew J. Wardlaw and Harry B Greenberg and Christina M. Parker and Eugene C. Butcher and David P. Andrew and William W. Agace},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={761 - 768}
}
The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial lymphocytes and lamina propria lymphocytes migrate to thymus-expressed chemokine (TECK). This attraction is mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor expressed at high levels by essentially all CD4(+) and CD8(+) T lymphocytes in the small intestine. Only a small subset of… CONTINUE READING
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