Lymphoadenopathy during Lyme Borreliosis Is Caused by Spirochete Migration-Induced Specific B Cell Activation

@inproceedings{Tunev2011LymphoadenopathyDL,
  title={Lymphoadenopathy during Lyme Borreliosis Is Caused by Spirochete Migration-Induced Specific B Cell Activation},
  author={Stefan S. Tunev and Christine J. Hastey and Emir Hodzic and Sunlian Feng and Stephen W. Barthold and Nicole Baumgarth},
  booktitle={PLoS pathogens},
  year={2011}
}
Lymphadenopathy is a hallmark of acute infection with Borrelia burgdorferi, a tick-borne spirochete and causative agent of Lyme borreliosis, but the underlying causes and the functional consequences of this lymph node enlargement have not been revealed. The present study demonstrates that extracellular, live spirochetes accumulate in the cortical areas of lymph nodes following infection of mice with either host-adapted, or tick-borne B. burgdorferi and that they, but not inactivated spirochetes… CONTINUE READING
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