Lymphatic transport and catabolism of therapeutic proteins after subcutaneous administration to rats and dogs.

@article{Wang2012LymphaticTA,
  title={Lymphatic transport and catabolism of therapeutic proteins after subcutaneous administration to rats and dogs.},
  author={Weirong Wang and Nancy Chen and Xiaolan Shen and P. Cunningham and Scott E. Fauty and Kimberly B Michel and Bo Wang and Xuening Hong and Christine M. Adreani and Christian N. Nunes and Chris Johnson and Kuo-chang Yin and Michelle A Groff and Yan Zou and Liming Liu and Lora Hamuro and Thomayant Prueksaritanont},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 5},
  pages={952-62}
}
The mechanism underlying subcutaneous absorption of macromolecules and factors that can influence this process were studied in rats using PEGylated erythropoietins (EPOs) as model compounds. Using a thoracic lymph duct cannulation (LDC) model, we showed that PEGylated EPO was absorbed from the subcutaneous injection site mainly via the lymphatic system in rats, which is similar to previous reports in sheep. After subcutaneous administration, the serum exposure was reduced by ∼70% in LDC animals… CONTINUE READING