Lymphatic filariasis: detection of circulating and urinary antigen and differences in antibody isotypes complexed with circulating antigen between symptomatic and asymptomatic subjects.

@article{Lutsch1988LymphaticFD,
  title={Lymphatic filariasis: detection of circulating and urinary antigen and differences in antibody isotypes complexed with circulating antigen between symptomatic and asymptomatic subjects.},
  author={Charles Lutsch and Jean Yves Cesbron and Deborah R Henry and Jean Paul Dessaint and K Wandji and Muhammad Ismail and Andr{\'e} Capron},
  journal={Clinical and experimental immunology},
  year={1988},
  volume={71 2},
  pages={253-60}
}
A two-site immunoradiometric assay using a monoclonal antibody (MoAb) against Brugia malayi microfilariae allowed the detection of parasite molecules both in the serum and the urine of patients from Sri Lanka infected with Wuchereria bancrofti. Whereas 50% of patients had no antigen in their serum, all of them excreted detectable amounts of antigen in their urine, the levels being higher in symptomatic than in asymptomatic patients. The poor detection in serum appeared to be related to the… CONTINUE READING