Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis.

@article{Schledzewski2006LymphaticEH,
  title={Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis.},
  author={Kai Schledzewski and Martin Falkowski and Gerhard Moldenhauer and Pat Metharom and Julia G. Kzhyshkowska and Ruth Ganss and Alexandra Demory and Berit Falkowska-Hansen and Hjalmar Kurzen and Selma Ugurel and Gernot Geginat and Bernd Arnold and Sergij Goerdt},
  journal={The Journal of pathology},
  year={2006},
  volume={209 1},
  pages={67-77}
}
Lymphangiogenesis is a novel prognostic parameter for several cancers that is preferentially quantified by immunohistochemistry of the lymphatic endothelium-specific hyaluronan receptor LYVE-1. Recently, the specificity of LYVE-1 was challenged by serendipitous observations of LYVE-1 expression in rare tissue macrophages. As expression of the hyaluronan receptor-like molecule stabilin-1 is shared by sinusoidal endothelium and macrophages, a thorough analysis of LYVE-1 expression was performed… CONTINUE READING

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