Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.

  title={Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.},
  author={Marika J. Karkkainen and Kari Alitalo},
  journal={Seminars in cell & developmental biology},
  volume={13 1},
Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic… CONTINUE READING


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