Lymphangioleiomyomatosis - a wolf in sheep's clothing.

  title={Lymphangioleiomyomatosis - a wolf in sheep's clothing.},
  author={Elizabeth P Henske and Francis X McCormack},
  journal={The Journal of clinical investigation},
  volume={122 11},
Lymphangioleiomyomatosis (LAM) is a rare progressive lung disease of women. LAM is caused by mutations in the tuberous sclerosis genes, resulting in activation of the mTOR complex 1 signaling network. Over the past 11 years, there has been remarkable progress in the understanding of LAM and rapid translation of this knowledge to an effective therapy. LAM pathogenic mechanisms mirror those of many forms of human cancer, including mutation, metabolic reprogramming, inappropriate growth and… CONTINUE READING


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