Lymphangiogenesis and lymphatic metastasis in breast cancer.

  title={Lymphangiogenesis and lymphatic metastasis in breast cancer.},
  author={Sophia Ran and Lisa D Volk and Kelly L. Hall and Michael J. Flister},
  journal={Pathophysiology : the official journal of the International Society for Pathophysiology},
  volume={17 4},
Lymphatic metastasis is the main prognostic factor for survival of patients with breast cancer and other epithelial malignancies. Mounting clinical and experimental data suggest that migration of tumor cells into the lymph nodes is greatly facilitated by lymphangiogenesis, a process that generates new lymphatic vessels from pre-existing lymphatics with the aid of circulating lymphatic endothelial progenitor cells. The key protein that induces lymphangiogenesis is vascular endothelial growth… CONTINUE READING
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