Lymph node stroma broaden the peripheral tolerance paradigm.

  title={Lymph node stroma broaden the peripheral tolerance paradigm.},
  author={Anne L Fletcher and Deepali Malhotra and Shannon J. Turley},
  journal={Trends in immunology},
  volume={32 1},
Research into how self-reactive T cells are tolerized in lymph nodes has focused largely on dendritic cells (DCs). We now know that lymph node stromal cells (LNSC) are important mediators of deletional tolerance to peripheral tissue-restricted antigens (PTAs), which are constitutively expressed and presented by LNSCs. Of the major LNSC subsets, fibroblastic reticular cells and lymphatic endothelial cells are known to directly induce tolerance of responding naïve CD8 T cells. The biological… CONTINUE READING

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