Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

@inproceedings{Fletcher2010LymphNF,
  title={Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions},
  author={Anne L Fletcher and Veronika Lukacs-Kornek and Erika D. Reynoso and Sophie E. Pinner and Ang{\'e}lique Bellemare-Pelletier and Mark S. Curry and Ai-ris Collier and Richard L. Boyd and Shannon J. Turley},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
Lymph node stromal cells (LNSCs) can induce potent, antigen-specific T cell tolerance under steady-state conditions. Although expression of various peripheral tissue-restricted antigens (PTAs) and presentation to naive CD8+ T cells has been demonstrated, the stromal subsets responsible have not been identified. We report that fibroblastic reticular cells (FRCs), which reside in the T cell zone of the LN, ectopically express and directly present a model PTA to naive T cells, inducing their… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 130 extracted citations

Breakdown in peripheral immune tolerance in experimental Diabetes Mellitus Alex

M. Kamyshnyi, Denis A. Putilin, Vita A. Kamyshna
2016
View 6 Excerpts
Highly Influenced

Promotion and prevention of autoimmune disease by CD8+ T cells.

Journal of autoimmunity • 2013
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Deletional selftolerance to a melanocyte / melanoma antigen derived from tyrosinase is mediated by a radioresistant cell in peripheral and mesenteric lymph nodes

L. A. Nichols, T. A. Colella, C. L. Bennett, B. E. Clausen, V. H. Engelhard
Proc . Natl . Acad . Sci . USA . • 2007
View 9 Excerpts
Highly Influenced

Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 3 Excerpts
Highly Influenced

Toll - like receptors 3 and 4 are expressed by human bone marrowderived mesenchymal stem cells and can inhibit their T - cell modulatory activity by impairing Notch signal

V. Lisi
Nat . Immunol . • 2008

Similar Papers

Loading similar papers…