Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

  title={Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions},
  author={Anne L Fletcher and Veronika Lukacs-Kornek and Erika D. Reynoso and Sophie E. Pinner and Ang{\'e}lique Bellemare-Pelletier and Mark S. Curry and Ai-ris Collier and Richard L. Boyd and Shannon J. Turley},
  booktitle={The Journal of experimental medicine},
Lymph node stromal cells (LNSCs) can induce potent, antigen-specific T cell tolerance under steady-state conditions. Although expression of various peripheral tissue-restricted antigens (PTAs) and presentation to naive CD8+ T cells has been demonstrated, the stromal subsets responsible have not been identified. We report that fibroblastic reticular cells (FRCs), which reside in the T cell zone of the LN, ectopically express and directly present a model PTA to naive T cells, inducing their… CONTINUE READING
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