Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.

@article{Legge2005LymphND,
  title={Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.},
  author={Kevin L. Legge and Thomas Braciale},
  journal={Immunity},
  year={2005},
  volume={23 6},
  pages={649-59}
}
The lethal outcome of high-dose pulmonary virus infection is thought to reflect high-level, sustained virus replication and associated lung inflammation prior to development of an adaptive immune response. Herein, we demonstrate that the outcome of lethal/sublethal influenza infection instead correlates with the initial virus replication tempo. Furthermore, the magnitude of early lung antiviral CD8+ T cell responses varies inversely with inoculum dose and is controlled by lymph-node-resident… CONTINUE READING