Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection.

@article{Grevenynghe2008LymphNA,
  title={Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection.},
  author={Julien van Grevenynghe and Rabih Halwani and Nicolas Chomont and Petronela Ancuta and Yoav Peretz and Andr{\'e} Tanel and Francesco Andrea Procopio and Yu Xiu Shi and Elias A Said and Elias K Haddad and Rafick Pierre S{\'e}kaly},
  journal={Seminars in immunology},
  year={2008},
  volume={20 3},
  pages={196-203}
}
Lymph nodes (LNs) represent the principal site where antigen-specific memory T- and B-cell responses are primed and differentiated into memory and effector cells. During chronic viral infections such as HIV, these lymphoid tissues undergo substantial structural changes. These changes are mostly caused by an imbalanced cytokine milieu, hyper-immune… CONTINUE READING