Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

  title={Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines},
  author={Yoshinori Fukazawa and Haesun Park and Mark J Cameron and François Lefebvre and Richard Lum and Noel Coombes and Eisa Mahyari and Shoko I. Hagen and Jin Young Bae and Marcelo Delos Reyes and Tonya Swanson and Alfred W. Legasse and Andrew W. Sylwester and Scott G Hansen and Andrew T. Smith and Petra Stafova and Rebecca Shoemaker and Yuan Li and Kelli Oswald and Michael K Axthelm and Adrian B McDermott and Guido Ferrari and David C. Montefiori and Paul Thatcher Edlefsen and Michael J. Piatak and Jeffrey D Lifson and Rafick Pierre S{\'e}kaly and Louis J. Picker},
  booktitle={Nature Medicine},
Live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) remain the most efficacious of all vaccines in nonhuman primate models of HIV and AIDS, yet the basis of their robust protection remains poorly understood. Here we show that the degree of LAV-mediated protection against intravenous wild-type SIVmac239 challenge strongly correlates with the magnitude and function of SIV-specific, effector-differentiated T cells in the lymph node but not with the responses of such T cells in the… CONTINUE READING
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