Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities.

  title={Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities.},
  author={Allen C. Steere and Stephen E. Malawista and David R. Snydman and R E Shope and Warren A. Andiman and Martin R. Ross and F M Steele},
  journal={Arthritis and rheumatism},
  volume={20 1},
An epidemic form of arthritis has been occurring in eastern Connecticut at least since 1972, with the peak incidence of new cases in the summer and early fall. Its identification has been possible because of tight geographic clustering in some areas, and because of a characteristic preceding skin lesion in some patients. The authors studied 51 residents of three contiguous Connecticut communities -- 39 children and 12 adults -- who developed an illness characterized by recurrent attacks of… 

Figures and Tables from this paper

The long-term course of Lyme arthritis in children.

The course of initially untreated Lyme disease in children may include acute infection followed by attacks of arthritis and then by keratitis, subtle joint pain, or chronic encephalopathy.

Erythema chronicum migrans and Lyme arthritis. The enlarging clinical spectrum.

Thirty-two patients with the onset of erythema chronicum migrans, Lyme arthritis, or both in mid-1976 were studied prospectively, and the diagnostic marker is the skin lesion.

The clinical evolution of Lyme arthritis.

To determine the clinical evolution of Lyme arthritis, 55 patients who did not receive antibiotic therapy for erythema chronicum migrans were followed longitudinally for a mean duration of 6 years.

Rheumatic manifestations in Lyme borreliosis.

The clinical spectrum and treatment of Lyme disease.

For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin, which is effective for the later stages of the disease.

Chronic Lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis.

Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.

Lyme arthritis: not confined to the East Coast.

In three contiguous Connecticut communities, Steere et al 1 studied the cases of 51 residents who had an illness characterized by a symmetric swelling and pain in a few large joints, some of them with an edematous papule that developed into an expanding red annular.

Lyme Disease

  • B. Krafchik
  • Medicine
    International journal of dermatology
  • 1989
In 1975, two mothers reported a clustering of arthritis cases in three communities on the east side of the Connecticut River, one of them being the small town of Lyme, which became known as lyme disease in 1979.

Lyme arthritis in Southern Norway - an endemic area for Lyme Borreliosis

All LA patients responded favourable to antibiotic treatment and none of the patients developed chronic arthritis after long term follow up, not even in LA patients who had intraarticular glucocorticosteroid (GC) injection prior to antibiotics.



Arthritis associated with Yersinia enterocolitica infection.

A significant reduction in the Y.enterocolitica titer took place within three months in every case, and the duration of the arthritis was from one week to five months in the 15 cases in which the arthritis subsided during the follow-up period of eight to eleven months.

Erythema chronicum migrans and Lyme arthritis: cryoimmunoglobulins and clinical activity of skin and joints.

The presence of serum cryoimmunoglobulins in patients with attacks of a newly described epidemic arthritis--Lyme arthritis--and in some patients with a characteristic skin lesion that sometimes precedes the onset of the arthritis are reported.

Juvenile rheumatoid arthritis: a review.

Observations suggest that what is now called JRA may in fact be more than a single disease, and recognition of these disease patterns is useful in the diagnosis and care of children with JRA.

An Experimental Epidemic of Reiter's Syndrome

It is concluded that Reiter's disease may occur as a sequella of bacillary dysentery, with a definite time relationship between the two disorders, that severe conjunctivitis appears to herald severe or recurrent arthritis, and that arthritis seems worst in joints previously weakened by other disease.


Recently, in the medical service of the Long Island College Hospital, a patient was observed who presented the clinical picture of Haverhill fever, and HaverHillia multiformis was isolated from the blood stream on seven occasions.

Clinical features and serologic abnormalities in juvenile rheumatoid arthritis.

Females with juvenile rheumatoid arthritis had a significanty higher incidence of antinuclear antibodies, greater variation in serum complement levels, and increased serum levels of IgA and IgM than did females with comparable disease activity.

Erythema chronicum migrans Afzelius in Americans.

A case seen at the USAF Hospital Wiesbaden (Germany) in an American stationed in Europe is reported to report a curious and rather infrequently seen disease in which a tick bite is followed by the appearance of a small ring of persistent, slightly elevated erythema.

Acute arthritis complicating rubella vaccination.

After a field trial of rubella virus vaccine (HPV-77 DK 12 strain), 329 children (2.8%) developed joint symptoms. Forty had complete rheumatologic evaluation and constitute the basis of this report.