Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model.

@article{Ardawi2016LycopeneTA,
  title={Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model.},
  author={Mohammed Salleh M Ardawi and Mohammed H M Badawoud and Sherif S Hassan and Abdulrahim A Rouzi and Jumanah M S Ardawi and Nouf M AlNosani and Mohammed Hassan Qari and Shaker A. Mousa},
  journal={Bone},
  year={2016},
  volume={83},
  pages={
          127-140
        }
}
Lycopene supplementation decreases oxidative stress and exhibits beneficial effects on bone health, but the mechanisms through which it alters bone metabolism in vivo remain unclear. The present study aims to evaluate the effects of lycopene treatment on postmenopausal osteoporosis. Six-month-old female Wistar rats (n=264) were sham-operated (SHAM) or ovariectomized (OVX). The SHAM group received oral vehicle only and the OVX rats were randomized into five groups receiving oral daily lycopene… CONTINUE READING
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