Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway.

@article{Qu2011LycopenePA,
  title={Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway.},
  author={Mingyue Qu and Zhou Zhou and Chun-hai Chen and Min Li and Liping Pei and Fang Hua Chu and Ju Yang and Yuan Wang and Li Li and Chuan Liu and Lei Zhang and Guangbin Zhang and Zheng-ping Yu and Denggao Wang},
  journal={Neurochemistry international},
  year={2011},
  volume={59 8},
  pages={1095-103}
}
Lycopene is a potent free radicals scavenger with demonstrated protective efficacy in several experimental models of oxidative damage. Trimethyltin (TMT) is an organotin compound with neurotoxic effects on the hippocampus and other limbic structures and is used to model neurodegenerative diseases targeting these brain areas. Oxidative stress is widely accepted as a central pathogenic mechanism of TMT-mediated neurotoxicity. The present study investigated whether the plant carotene lycopene… CONTINUE READING

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