Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB.

@article{Chiang2007LycopeneIP,
  title={Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB.},
  author={Han-Sun Chiang and Wen-Bin Wu and Jia-You Fang and Der-Fang Chen and Bing-Huei Chen and Chieh-Chen Huang and Ying-ting Chen and Chi-Feng Hung},
  journal={Life sciences},
  year={2007},
  volume={81 21-22},
  pages={
          1509-17
        }
}
In melanoma development and progression, platelet-derived growth factor (PDGF) has been suggested to modulate the microenvironment, especially stromal fibroblasts, to the benefit of melanoma growth, invasion, and metastasis. Lycopene, a natural carotenoid that is abundant in tomato, has been shown to inhibit proliferation of several types of cancer cells. However, little attention has been paid to skin fibroblasts and melanoma cells. In the present study, we determined the effects of lycopene… Expand
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TLDR
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Mechanism of the Anticancer Effect of Lycopene (Tetraterpenoids).
TLDR
Data is reviewed on the cancer preventive activities of lycopene, possible mechanisms involved, and the relationship between lycopenes consumption and human cancer risk. Expand
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TLDR
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Investigating into anti-cancer potential of lycopene: Molecular targets.
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References

SHOWING 1-10 OF 21 REFERENCES
Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells.
TLDR
The results provide the first evidence showing that lycopene inhibits PDGF-BB-induced signaling, proliferation and migration in rat A10 and aortic SMCs. Expand
Mechanism of action and in vivo role of platelet-derived growth factor.
TLDR
Structural and functional properties of PDGF and PDGF receptors, the mechanism whereby PDGF exerts its cellular effects, and the role ofPDGF in normal and diseased tissues are discussed. Expand
Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB.
TLDR
It is reported here that platelet-derived growth factor-BB (PDGF-BB) is the major promotility factor in human serum for HDF motility on type I collagen and recapitulates the full promotility activity of human serum and anti-PDGF neutralizing antibodies completely block it. Expand
Platelet-derived growth factor in chemotactic for fibroblasts
TLDR
PDGF could have two functions in wound healing: to attract fibroblasts to migrate into the clot and then to induce their proliferation, and to stimulate chemotaxis rather than random motility. Expand
(−)‐Epigallocatechin‐3‐gallate, a polyphenolic compound from green tea, inhibits fibroblast adhesion and migration through multiple mechanisms
TLDR
First evidence is provided that EGCG is an effective inhibitor on behaviors of the stromal fibroblasts, affecting their adhesion and migration, in a non‐contact coculture system. Expand
Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle.
TLDR
This review describes the vascular biology of PDGF and focuses on recent findings regarding the intracellular signals activated by PDGF in the context of vascular smooth muscle cell proliferation, migration and, contraction. Expand
Overview of Mechanisms of Action of Lycopene
  • D. Heber, Q. Lu
  • Biology, Medicine
  • Experimental biology and medicine
  • 2002
TLDR
A review will focus on the growing body of evidence that carotenoids have unexpected biologic effects in experimental systems, some of which may contribute to their cancer preventive properties in models of carcinogenesis. Expand
Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil
TLDR
The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis and an understanding of this process is of great importance for the development of effective therapeutical strategies to treat melanoma. Expand
Melanoma-stroma interactions: structural and functional aspects.
TLDR
It is hypothesised that stromal activation, as seen in tumor ulceration or immunological regression in melanoma, stimulates tumour progression and is topographically linked to different areas in and around the tumour. Expand
PDGF receptors as cancer drug targets.
The benefits of combining PDGF antagonists and VEGF antagonists in a mouse model of pancreatic islet cancer are shown in a report by Bergers et al.: Bergers, G., Song, S., Meyer-Morse, N., Bergsland,Expand
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