Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways.

@article{Chan2009LycopeneIP,
  title={Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways.},
  author={C. Chan and Jia-You Fang and Hsin-Huang Lin and Chi-Yea Yang and Chi-Feng Hung},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={388 1},
  pages={172-6}
}
Retinal pigment epithelial (RPE) cells play a dominant role in the development of proliferative vitreoretinopathy (PVR), which is the leading cause of failure in retinal reattachment surgery. Several studies have shown that platelet-derived growth factor (PDGF) exhibits chemotaxis and proliferation effects on RPE cells in PVR. In this study, the inhibitory effect of lycopene on PDGF-BB-induced ARPE19 cell migration is examined. In electric cell-substrate impedance sensing (ECIS) and Transwell… CONTINUE READING

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