Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate.

  title={Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate.},
  author={Humberto Reis Matos and Vera L{\'u}cia Capelozzi and Osmar F Gomes and P. Di Mascio and Marisa H G Medeiros},
  journal={Archives of biochemistry and biophysics},
  volume={396 2},
Experimental and epidemiological evidence suggests that lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, may play a role in preventing certain cancers in humans. We have investigated the effect of lycopene pretreatment on lipid peroxidation, oxidative damage to DNA, and histopathological changes in liver of animals subjected to intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) administration. Compared with control rats, liver of Fe-NTA-treated… CONTINUE READING
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Lycopene inhibits DNA damage and reduces hMTH1 mRNA expression in the liver of Mongolian gerbils treated with ferric nitrilotriacetate.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2011
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