Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells.

@article{Lo2007LycopeneBP,
  title={Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells.},
  author={Huey-ming Lo and Chi-Feng Hung and Yu-Lun Tseng and Bing-Huei Chen and Jr-Shian Jian and Wen-Bin Wu},
  journal={Biochemical pharmacology},
  year={2007},
  volume={74 1},
  pages={
          54-63
        }
}
  • H. Lo, C. Hung, +3 authors W. Wu
  • Published 2007
  • Biology, Medicine
  • Biochemical pharmacology
Cardiovascular diseases (CVDs) result from the sub-endothelial accumulation of inflammatory cells and smooth muscle cells (SMCs). Lycopene, a natural compound from tomato, has been suggested to play a role in CVD prevention. However, its action mechanism is still largely unknown. In this study, we examined the effect of lycopene on SMCs. We found that preincubation of PDGF-BB with lycopene resulted in a marked inhibition on PDGF-BB-induced PDGF receptor-beta (PDGFR-beta), PLCgamma, and ERK1/2… Expand
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