Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum.

  title={Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum.},
  author={Kan’ichiro Ishiuchi and Takaaki Kubota and Haruaki Ishiyama and Shigeki Hayashi and Toshiro Shibata and Koichiro Mori and Yutaro Obara and Norimichi Nakahata and Jun’ichi Kobayashi},
  journal={Bioorganic \& medicinal chemistry},
  volume={19 2},

Lycoplanines B-D, Three Lycopodium Alkaloids from Lycopodium complanatum

A novel C17N Lycopodium alkaloid (LA), lycoplanine B (1), containing an unusual formyl group, along with two new LAs, lycoplanines C (2) and D (3), were isolated from the whole plant of Lycopodium

Lyconadins G and H, Two Rare Lyconadin-Type Lycopodium Alkaloids from Lycopodium complanatum

It is the first time to establish the absolute configuration of lyconadin-type Lycopodium alkaloid by an X-ray diffraction experiment and may provide more information for the biosynthesis of Lyconadins.

Lycopodium Alkaloids from Diphasiastrum complanatum

One new lycopodine-type Lycopodium alkaloid, dehydroisofawcettiine N-oxide (1) and eleven known analogues (2–12) were isolated from the whole plant of Diphasiastrum complanatum. The new structure was

Lycojaponicumins A-C, three alkaloids with an unprecedented skeleton from Lycopodium japonicum.

Lycojaponicumins A-C (1-3), three trace alkaloids isolated from Lycopodium japonicum, represent a unique heterocyclic skeleton formed by the new linkage C4-C9, and are the first examples of natural products possessing a 5/5/5 /5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety.

Synthetic studies on pseudo-dimeric Lycopodium alkaloids: total synthesis of complanadine B.

Complanadines A and B (1 and 2, Figure 1) are dimeric Lycopodium alkaloids in the lycodine family that possess significant activity for nerve growth factor (NGF) production from human glial cells.i,

Abietane diterpenoids from Lycopodium complanatum.





A new alkaloid, lycodine, C17H24N2, m.p. 118°, has been isolated from Lycopodium annotinum. Lycodine is a tetracyclic diacidic base containing a secondary nitrogen atom, a 2,3-disubstituted pyridine

The Lycopodium alkaloids.

This review covered the structure elucidation and biological activity of new Lycopodium alkaloids and total synthesis of some Lycop sodium alkaloid reported in the literature from 2004 to July in 2008.

Fastigiatine, a lycopodium alkaloid with a new ring system

Fastigiatine, C19H28N2O, is a minor component of the alkaloids of Lycopodiumfastigiatum R•Br•collected in New Zealand. Its structure and relative configuration have been resolved by an X-ray analys...

The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

Huperzine A and B, two new Lycopodium alkaloids isolated from Huperziaserrata (Thunb.) Trev., are shown to possess structures 1 and 3, respectively, on the basis of chemical and spectroscopic data.

Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion.

A total synthesis of the Lycopodium alkaloid (+)-complanadine A is described. Complanadine A has been shown to induce the secretion of neurotrophic factors from 1321N1 cells, promoting the

The Lycopodium alkaloids.

The effect of HupA and other cholinesterase inhibitors (anti-AD drugs) on acetylcholine esterase activity in the rat cortex and butylCholine esters activity are compared.