Lycium chinensis Mill attenuates glutamate induced oxidative toxicity in PC12 cells by increasing antioxidant defense enzymes and down regulating ROS and Ca2+ generation

 Lycium chinensis Mill attenuates glutamate induced oxidative toxicity in PC12 cells by increasing antioxidant defense enzymes and down regulating ROS and Ca2+ generation},
  author={Opeyemi Joshua Olatunji and Hongxia Chen and Yifeng Zhou},
  journal={Neuroscience Letters},
Flavonoids of Kudzu Root Fermented by Eurtotium cristatum Protected Rat Pheochromocytoma Line 12 (PC12) Cells against H2O2-Induced Apoptosis
Reversed-phase high performance liquid chromatography (RP-HPLC) showed that isoflavonoid compounds of kudzu root fermented by Eurtotium cristatum and extracted using de-ionized water were higher active compared with non-fermented.
Neuroprotective and Cognition-Enhancing Effects of Compound K Isolated from Red Ginseng.
Compound K could be useful in prevention and treatment of reactive oxygen species-induced neurological disorders such as Alzheimer's disease, and its cytoprotective effect was abolished by heme oxygenase-1 inhibitor, tin protophorphyrin IX.
Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats
The present study has revealed that L. chinenseMill possess anti‐hyperglycemic and anti-hyperlipidemic properties which is mediated through modulation of oxidative stress and polyphenolics might be responsible for the action.
Protective Effects of An Enzymatic Hydrolysate from Octopus ocellatus Meat against Hydrogen Peroxide-Induced Oxidative Stress in Chang Liver Cells and Zebrafish Embryo.
Results suggest that OOMAH possesses antioxidant bioactivities and could provide protective effects against H2O2-induced oxidative stress and might be used as a potential resource of functional foods.
Immunomodulatory Effects of Lycium barbarum Polysaccharide Extract and Its Uptake Behaviors at the Cellular Level
The immunomodulatory effects of LBP and its effective uptake by macrophages and intestine are demonstrated and both pro-inflammatory and anti-inflammatory effects are suggested.
LbNR-Derived Nitric Oxide Delays Lycium Fruit Coloration by Transcriptionally Modifying Flavonoid Biosynthetic Pathway
It is found that nitric oxide production during Lycium fruit ripening decreased progressively presenting a negative relationship with anthocyanins, and it was further found that NO acts by antagonizing the ABA signaling, a phytohormone the authors have previously shown playing a positive role in Ly calcium fruit coloration.


Protective effect of a polysaccharide isolated from a cultivated Cordyceps mycelia on hydrogen peroxide‐induced oxidative damage in PC12 cells
Pretreatment of PC12 cells with APS significantly increased the survival of cells and the activities of glutathione peroxidase, catalase (CAT) and superoxide dismutase (SOD), and reduced the levels of LDH and MDA.
Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.
  • N. Cho, J. Choi, S. Sung
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2012
Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells.
Neuroprotective Effects of Biochanin A Against Glutamate-Induced Cytotoxicity in PC12 Cells Via Apoptosis Inhibition
Results indicate that biochanin A may be able to exert neuroprotective effects against l-glutamate-induced cytotoxicity and imply thatBiochanin B may act as an antiapoptotic agent in order to perform its protective function.
Evaluation of Samjunghwan, a traditional medicine, for neuroprotection against damage by amyloid-beta in rat cortical neurons.
Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress