Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation.

@article{Olatunji2018LyciumCL,
  title={Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation.},
  author={Opeyemi Joshua Olatunji and Hongxia Chen and Yifeng Zhou},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2018},
  volume={102},
  pages={
          1145-1151
        }
}
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Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro-inflammatory responses in rats.
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References

SHOWING 1-10 OF 60 REFERENCES
Protective Effects of Luteolin on Diabetic Nephropathy in STZ-Induced Diabetic Rats
TLDR
The results suggested that protection against development of diabetic nephropathy by luteolin treatment involved changes in superoxide dismutase activity, the malondialdehyde content and expression of Heme Oxygenase-1 (HO-1) protein.
Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress
TLDR
This study supports the hypothesis that AS-IV reduces proteinuria and attenuates diabetes, which is associated with decreased ER stress, and might be an important mechanism in the renoprotective function of As-IV in the pathogenesis of DN.
Chaihuang-Yishen Granule Inhibits Diabetic Kidney Disease in Rats through Blocking TGF-β/Smad3 Signaling
TLDR
Treatment with Chaihuang-Yishen granule attenuated diabetic kidney injury by significantly inhibiting 24-h proteinuria and progressive renal fibrosis including glomerulosclerotic index, tubulointerstitial fibrosis index, and upregulation of extracellular matrix despite the same levels of blood glucose.
Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice
TLDR
The data from present study suggest that BBR can ameliorate tubulointerstitial fibrosis in DN by activating Nrf2 pathway and inhibiting TGF-β/Smad/EMT signaling activity.
Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats
TLDR
The present study has revealed that L. chinenseMill possess anti‐hyperglycemic and anti-hyperlipidemic properties which is mediated through modulation of oxidative stress and polyphenolics might be responsible for the action.
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