Lycium barbarum Polysaccharide Promotes Nigrostriatal Dopamine Function by Modulating PTEN/AKT/mTOR Pathway in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Murine Model of Parkinson’s Disease

  title={Lycium barbarum Polysaccharide Promotes Nigrostriatal Dopamine Function by Modulating PTEN/AKT/mTOR Pathway in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Murine Model of Parkinson’s Disease},
  author={Xiaohong Wang and Lei Pang and Yanqing Zhang and Jiang Xu and Dongyi Ding and Tianli Yang and Qian-Ming Zhao and Fan Wu and Fei Li and Haiwei Meng and Duonan Yu},
  journal={Neurochemical Research},
To investigate the effects of Lycium barbarum polysaccharide (LBP) on pathological symptoms and behavioral deficits in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease (PD) mouse model. The therapeutic effects of LBP were monitored with an Open field test, a Rotarod test and a Morris water maze test. We also investigated the mechanisms with qRT-PCR and Western blotting analyses. After a relatively short-term LBP treatment, the total distance and walking time of PD… 

Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease

Interestingly, administration of Lycium barbarum polysaccharide (LBP) improved the motor ability, dopamine level, and TH activity, and the oxidative damage was concomitant reduced in the silkworm PD model.

Protective effects of Lycium barbarum polysaccharide (LBP) on rats with renal ischemia-reperfusion injury (IRI)

LBP can exert protective effects on RIRI via improving oxidative stress (OS), suppressing apoptosis, and decreasing secretion and inflammatory cytokines.

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

The relationship between AKT signaling pathway and AD and PD is reviewed, and the potential natural products based on the PI3K/AKT pathway to treat two diseases in recent years are discussed, hoping to provide guidance and reference for this field.

Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

The experimental and theoretical evidence to use LBPs for the treatment of aging-related neurological diseases and stroke-induced neural injuries is provided and the molecular mechanisms of LBPs in playing neuroprotective roles are further explored.

Lycium Barbarum Polysaccharide Induce the Neuronal Differentiation of Mesenchymal Stem Cell for Potential Application in Neural Regeneration

It is demonstrated that the directional differentiation process of BMSCs can be partially regulated by LBP, and this strategy may provide opportunities for physician to improve the effectiveness of stem cell therapy for the treatment of degenerative cerebrovascular disease.

The Potential of Edible and Medicinal Resource Polysaccharides for Prevention and Treatment of Neurodegenerative Diseases

The potential of polysaccharides to prevent neurodegeneration by their regulation of behavioral and major pathologies, including abnormal protein aggregation and neuronal damage caused by neuronal apoptosis, autophagy, oxidative damage, neuroinflammation, unbalanced neurotransmitters, and poor synaptic plasticity is evaluated.

Overview on the Pharmacological Functions of Polysaccharides from Lycium Barbarum

Traditional Chinese herb Lycium barbarum (also called Goji berries, wolfberry), popular for its biological and pharmacological functions, is widely grown in the dry or semidry regions of China (such

The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine.

Promising drug targets and associated therapeutic interventions in Parkinson’s disease

Limits of current therapeutic options in PD, novel drug targets for PD, and the role of some critical beneficial natural products to control the progression of PD are compiled.

Protective Effects of Lycium barbarum Polysaccharide on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway

It is demonstrated that LBP prevents 6-OHDA-induced apoptosis in PC12 cells, at least in part through the ROS-NO pathway.

Lycium barbarum Polysaccharide Prevents Focal Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis in Mice

It is proposed that LBP protects against focal cerebral ischemic injury by attenuating the mitochondrial apoptosis pathway and attenuated the neuronal apoptosis.

Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma☆

Et-1 expression was up-regulated in the retina in COH model and the neuroprotective effect of LBP might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature.

Activation of the Nrf2/HO-1 Antioxidant Pathway Contributes to the Protective Effects of Lycium Barbarum Polysaccharides in the Rodent Retina after Ischemia-Reperfusion-Induced Damage

Results suggested that LBP partially exerted its beneficial neuroprotective effects via the activation of Nrf2 and an increase in HO-1 protein expression in the retina after I/R injury.

Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

It is shown that LAMP2A downregulation resulted in progressive loss of nigral dopaminergic neurons, severe reduction in striatal dopamine levels/terminals, increased astro- and microgliosis and relevant motor deficits and suggests that CMA impairment may underlie PD pathogenesis.

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity

Importantly, neuroprotective function of 6-Bio as envisaged by immunohistology and behavior analyses in a preclinical model of PD where it induces autophagy in dopaminergic neurons of mice midbrain to clear toxic protein aggregates suggesting that it could be a potential therapeutic candidate for protein conformational disorders.

Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats.

  • X-M Li
  • Medicine
    International journal of biological macromolecules
  • 2007