Lyar-Mediated Recruitment of Brd2 to the Chromatin Attenuates Nanog Downregulation Following Induction of Differentiation.

@article{LunaPelez2018LyarMediatedRO,
  title={Lyar-Mediated Recruitment of Brd2 to the Chromatin Attenuates Nanog Downregulation Following Induction of Differentiation.},
  author={Noelia Luna-Pel{\'a}ez and M. Garc{\'i}a-Dom{\'i}nguez},
  journal={Journal of molecular biology},
  year={2018},
  volume={430 8},
  pages={
          1084-1097
        }
}
  • Noelia Luna-Peláez, M. García-Domínguez
  • Published 2018
  • Biology, Medicine
  • Journal of molecular biology
  • During development, cellular differentiation programs need tight regulation for proper display of the activity of multiple factors in time and space. Chromatin adaptors of the BET family (Brd2, Brd3, Brd4 and Brdt in vertebrates) are transcription co-regulators tightly associated with the progression of the cell cycle. A key question regarding their function is whether they work as part of the general transcription machinery or, on the contrary, they are precisely recruited to the chromatin… CONTINUE READING
    6 Citations
    LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA
    • 3
    • PDF
    Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system
    • 1
    • PDF

    References

    SHOWING 1-10 OF 46 REFERENCES
    Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.
    • 95
    • PDF
    The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase*
    • 184
    • PDF
    Brd4 Recruits P-TEFb to Chromosomes at Late Mitosis To Promote G1 Gene Expression and Cell Cycle Progression
    • Z. Yang, Nanhai He, Qiang Zhou
    • Biology, Medicine
    • Molecular and Cellular Biology
    • 2007
    • 267
    • PDF
    Functions of BET proteins in erythroid gene expression.
    • 59
    • PDF
    The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.
    • 69