Lyar-Mediated Recruitment of Brd2 to the Chromatin Attenuates Nanog Downregulation Following Induction of Differentiation.

  title={Lyar-Mediated Recruitment of Brd2 to the Chromatin Attenuates Nanog Downregulation Following Induction of Differentiation.},
  author={Noelia Luna-Pel{\'a}ez and M. Garc{\'i}a-Dom{\'i}nguez},
  journal={Journal of molecular biology},
  volume={430 8},
  • Noelia Luna-Peláez, M. García-Domínguez
  • Published 2018
  • Biology, Medicine
  • Journal of molecular biology
  • During development, cellular differentiation programs need tight regulation for proper display of the activity of multiple factors in time and space. Chromatin adaptors of the BET family (Brd2, Brd3, Brd4 and Brdt in vertebrates) are transcription co-regulators tightly associated with the progression of the cell cycle. A key question regarding their function is whether they work as part of the general transcription machinery or, on the contrary, they are precisely recruited to the chromatin… CONTINUE READING
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