Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

  title={Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis},
  author={Daniel R. Getts and Rachael L. Terry and Meghann Teague Getts and Marcus Mueller and Sabita Rana and Bimmi Shrestha and Jane Radford and Nico Van Rooijen and Iain L Campbell and Nicholas J C King},
  journal={The Journal of Experimental Medicine},
  pages={2319 - 2337}
In a lethal West Nile virus (WNV) model, central nervous system infection triggered a threefold increase in CD45(int)/CD11b(+)/CD11c(-) microglia at days 6-7 postinfection (p.i.). Few microglia were proliferating, suggesting that the increased numbers were derived from a migratory precursor cell. Depletion of "circulating" (Gr1(-)(Ly6C(lo))CX3CR1(+)) and "inflammatory" (Gr1(hi)/Ly6C(hi)/CCR2(+)) classical monocytes during infection abrogated the increase in microglia. C57BL/6 chimeras… CONTINUE READING
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