Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages

@inproceedings{Morias2015Ly6CMR,
  title={Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages},
  author={Yannick Morias and Chlo{\'e} Abels and Damya Laoui and Eva Van Overmeire and Martin Guilliams and Elio Schouppe and Frank Tacke and Carlie J. deVries and Patrick de Baetselier and Alain Beschin and P. F. Loke},
  booktitle={PLoS pathogens},
  year={2015}
}
Monocytes consist of two well-defined subsets, the Ly6C+ and Ly6C- monocytes. Both CD11b+ myeloid cells populations have been proposed to infiltrate tissues during inflammation. While infiltration of Ly6C+ monocytes is an established pathogenic factor during hepatic inflammation, the role of Ly6C- monocytes remains elusive. Mice suffering experimental African trypanosome infection die from systemic inflammatory response syndrome (SIRS) that is initiated by phagocytosis of parasites by liver… CONTINUE READING