Ly6C(high) monocytes control cerebral toxoplasmosis.

@article{Biswas2015Ly6ChighMC,
  title={Ly6C(high) monocytes control cerebral toxoplasmosis.},
  author={Aindrila Biswas and Dunja Bruder and Susanne A Wolf and Andreas Jeron and Matthias Mack and Markus M Heimesaat and Ildiko Rita Dunay},
  journal={Journal of immunology},
  year={2015},
  volume={194 7},
  pages={3223-35}
}
Cerebral infection with the parasite Toxoplasma gondii is followed by activation of resident cells and recruitment of immune cells from the periphery to the CNS. In this study, we show that a subset of myeloid cells, namely Ly6C(high)CCR2(+) inflammatory monocytes that infiltrate the brain upon chronic T. gondii infection, plays a decisive role in host defense. Depletion of this monocyte subset resulted in elevated parasite load and decreased survival of infected mice, suggesting their crucial… CONTINUE READING
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