Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors.

  title={Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors.},
  author={Kathleen Marie Smith and Jerry Wu and A B Bakker and Joseph H. Phillips and Lewis L. Lanier},
  journal={Journal of immunology},
  volume={161 1},
Several members of the Ly-49 receptor family inhibit NK cell-mediated lysis of targets expressing appropriate MHC class I molecules. Ly-49D and Ly-49H, two Ly-49 molecules that lack immunoreceptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domains, associate with mouse DAP12, a molecule that possesses an immunoreceptor tyrosine-based activation motif (ITAM). Cotransfection of either Ly-49D or Ly-49H with DAP12 induces surface expression of both Ly-49 and DAP12. The Ly-49/DAP12… CONTINUE READING
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