Ly 2 positive cytotoxic T lymphocytes, whether specific or non-specific in lytic activity, may express a large, granular, vacuolated lymphocyte morphology.

@article{Wilson1984Ly2P,
  title={Ly 2 positive cytotoxic T lymphocytes, whether specific or non-specific in lytic activity, may express a large, granular, vacuolated lymphocyte morphology.},
  author={Anne M. Wilson and Roland Scollay and A P Abbot and Ken D Shortman},
  journal={The Australian journal of experimental biology and medical science},
  year={1984},
  volume={62 ( Pt 4)},
  pages={381-401}
}
Cytotoxic clones consisting entirely of large, vacuolated granular lymphocytes (LGL) are produced with high frequency when individual purified mature Ly 2+ T cells are cultured at limit dilution in the presence of concanavalin A and irradiated spleen filler cells. Similar cells are produced in cultures of Ly 2- T cells but in lower proportion, the level of… CONTINUE READING