Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

@inproceedings{Dirscherl2009LuteolinTG,
  title={Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype},
  author={Konstantin Dirscherl and Marcus Karlstetter and Stefanie Ebert and Dominik Kraus and Julia Hlawatsch and Yana Walczak and C. Moehle and Rudolf Fuchshofer and Thomas Langmann},
  booktitle={Journal of Neuroinflammation},
  year={2009}
}
Luteolin, a plant derived flavonoid, exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. Luteolin also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. To better understand the immuno-modulatory effects of this important flavonoid, we performed a genome-wide expression analysis in pro-inflammatory challenged microglia treated with luteolin… CONTINUE READING

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