Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.

@article{Xagorari2001LuteolinIA,
  title={Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.},
  author={Angeliki Xagorari and Andreas Papapetropoulos and A Mauromatis and Mary Economou and Theodore Fotsis and Charis Roussos},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={296 1},
  pages={181-7}
}
Flavonoids are naturally occurring polyphenolic compounds with a wide distribution throughout the plant kingdom. In the present study, we compared the ability of several flavonoids to modulate the production of proinflammatory molecules from lipopolysaccharide (LPS)-stimulated macrophages and investigated their mechanism(s) of action. Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and… CONTINUE READING
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