Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells

  title={Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells},
  author={Mano Horinaka and Tatsushi Yoshida and Takumi Shiraishi and Susumu Nakata and Miki Wakada and Ryoko Nakanishi and Hoyoku Nishino and Hiroshi Matsui and Toshiyuki Sakai},
Luteolin, a naturally occurring flavonoid, induces apoptosis in various cancer cells. Little is known however concerning the underlying molecular mechanisms responsible for this activity. In this report, we reveal a novel mechanism by which luteolin-induced apoptosis occurs, and show for the first time that the apoptosis by luteolin is mediated through death receptor 5 (DR5) upregulation. Luteolin markedly induced the expression of DR5, along with Bcl-2-interacting domain cleavage and the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 58 extracted citations

Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2008
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-9 of 9 references


H Ueda, C Yamazaki, M. Yamazaki
Pharm. Bull., 26, 560–563. • 2003
View 5 Excerpts
Highly Influenced


MS Sheikh, Y. Huang
Cancer Drug Targets, 4, 97–104. • 2004
View 2 Excerpts


MJ Dechant, J Fellenberg, CG Scheuerpflug, V Ewerbeck, KM. Debatin
J. Cancer, 109, 661–667. • 2004
View 2 Excerpts


YG Ren, KW Wagner, +3 authors QL. Deveraux
Biol. Cell., 11, 5064–5074. • 2004


WG Ko, TH Kang, SJ Lee, YC Kim, BH. Lee
Res., 16, 295–298. • 2002
View 1 Excerpt


J Wang, HJ Chun, W Wong, DM Spencer, MJ. Lenardo
Natl. Acad. Sci. USA, 98, 13884–13888. • 2001


H Yamada, S Tada-Oikawa, A Uchida, S. Kawanishi
Biophys. Res. Commun., 265, 130–133. • 1999
View 2 Excerpts


GS Wu, TF Burns, +12 authors WS. ElDeiry
Genet., 17, 141–143. • 1997


RM Pitti, SA Marsters, +3 authors A. Ashkenazi
Biol. Chem., 271, 12687–12690. • 1996

Similar Papers

Loading similar papers…