Corpus ID: 7082531

Luteolin induces apoptosis in mouse liver cancer cells through ROS mediated pathway: A mechanistic investigation

  title={Luteolin induces apoptosis in mouse liver cancer cells through ROS mediated pathway: A mechanistic investigation},
  author={W. Wang and F. Zhao and Jing Zhang and D. Gao},
  journal={Biomedical Research-tokyo},
Luteolin is a flavonoid and considered to be important for anti-cancer activity against many cancer cells. However its mechanism of action is poorly understood as well as systematics study on its action on different cancer cell line is still obscure. In this study we checked luteolin activity against number of cell line and according to our screen mouse liver cancer cells (HepG2) is found to be most susceptible to its action. We have also measured how different concentrations of luteolin… Expand
5 Citations
Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion.
The anticancer activities of apigenin, luteolin and myricetin were attributed to the alterations of ROS signaling, and as well as the induction of apoptosis, cell cycle arrest and abrogation of the invasion. Expand
Luteolin induces myelodysplastic syndrome‑derived cell apoptosis via the p53‑dependent mitochondrial signaling pathway mediated by reactive oxygen species.
The data suggested that luteolin exerts its pro‑apoptotic action partly through the p53‑dependent mitochondrial signaling pathway mediated by intracellular ROS, which provides a promising therapeutic candidate for patients with MDS. Expand
Flavonoids as Emerging Anticancer Agents: Current Trends and Recent Advances in Phytotherapy
The present chapter summarizes the purported cellular, molecular, and genetic mechanisms of anticancer action of flavonoids, such as apoptosis induction, cell cycle arrest, anti-angiogenesis,Anti-metastasis, and anti-inflammatory and antioxidant aspects. Expand
The potential therapeutic effect of Luteolin against Diethyl nitrosamine induced hepatocellular carcinoma in rats.
The efficacy of Luteolin supplementation as an anti-HCC treatment and as a chemo-sensitizer for Cisplatin treatment of HCC in rats are suggested. Expand
Luteolin induces apoptosis in mouse liver cancer cells through ROS mediated pathway: A mechanistic investigation
Quantitative real time PCR analysis results showed that luteolin significantly up-regulated the expression of both intrinsic and extrinsic caspases as well as executioner caspase, which clearly showed the details mechanistic pathway by which lutenolin is inducing apoptosis in HepG2. Expand


Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest
The apoptotic induction and cell cycle arrest function of luteolin on the liver cancer cells and the related mechanism may be through arresting cell cycle at phase G1/S, enhancing Bax level, reducing anti-apoptotic protein Bcl-2 level, resulting in activating caspase-3 enzyme and decrease of mitochondrial membrane potential, and finally leading to cell apoptosis. Expand
Luteolin induces apoptotic cell death through AIF nuclear translocation mediated by activation of ERK and p38 in human breast cancer cell lines
The data suggest that luteolin induces a caspase‐dependent and ‐independent apoptosis involving AIF nuclear translocation mediated by activation of ERK and p38 in breast cancer cells. Expand
Molecular mechanisms of luteolin-7-O-glucoside-induced growth inhibition on human liver cancer cells: G2/M cell cycle arrest and caspase-independent apoptotic signaling pathways
The results suggest that the anti-proliferative effect of LUT7G on HepG2 is associated with G2/M phase cell cycle arrest by JNK activation. Expand
Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK.
The data suggest that luteolin induced apoptosis via mechanisms involving mitochondria translocation of Bax/Bak and activation of JNK and inhibition of SP600125 suggest that hepatocellular carcinoma remains a major challenging clinical problem in many parts of the world. Expand
Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway.
It is concluded that luteolin induces apoptosis from G1 arrest via three signaling pathways of TGF‑β1, p53, and Fas/Fas-ligand in HCC cells. Expand
Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-κB modulation in HepG2 hepatocarcinoma cells.
It is proposed that AMPK is a novel regulator of NF-κB in luteolin-induced cancer cell death and is an attractive target for cancer prevention by flavonoids. Expand
Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells
The results suggest that luteolin may be used as potential chemopreventive and chemotherapeutic agents. Expand
Mitochondria Determine the Efficacy of Anticancer Agents that Interact with DNA but Not the Cytoskeleton
The results suggest that mtDNA is a potential target for the anticancer agents that interact with DNA to induce ROS-dependent apoptosis of cancer cells, whereas agents that affect the cytoskeleton induce cell death by a mitochondria- and ROS-independent mechanism. Expand
Inhibitory Effects and Mechanisms of Luteolin on Proliferation and Migration of Vascular Smooth Muscle Cells
The aim of this review is to summarize the existing inhibitory effects and mechanisms of luteolin on proliferation and migration of VSMCs, and consider whether luteolini may be a potential candidate for preventing and treating atherosclerosis. Expand
Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis.
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