Corpus ID: 7082531

Luteolin induces apoptosis in mouse liver cancer cells through ROS mediated pathway: A mechanistic investigation

@article{Wang2017LuteolinIA,
  title={Luteolin induces apoptosis in mouse liver cancer cells through ROS mediated pathway: A mechanistic investigation},
  author={W. Wang and F. Zhao and Jing Zhang and D. Gao},
  journal={Biomedical Research-tokyo},
  year={2017},
  volume={28},
  pages={839-845}
}
Luteolin is a flavonoid and considered to be important for anti-cancer activity against many cancer cells. However its mechanism of action is poorly understood as well as systematics study on its action on different cancer cell line is still obscure. In this study we checked luteolin activity against number of cell line and according to our screen mouse liver cancer cells (HepG2) is found to be most susceptible to its action. We have also measured how different concentrations of luteolin… Expand
5 Citations
Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion.
TLDR
The anticancer activities of apigenin, luteolin and myricetin were attributed to the alterations of ROS signaling, and as well as the induction of apoptosis, cell cycle arrest and abrogation of the invasion. Expand
Luteolin induces myelodysplastic syndrome‑derived cell apoptosis via the p53‑dependent mitochondrial signaling pathway mediated by reactive oxygen species.
TLDR
The data suggested that luteolin exerts its pro‑apoptotic action partly through the p53‑dependent mitochondrial signaling pathway mediated by intracellular ROS, which provides a promising therapeutic candidate for patients with MDS. Expand
Flavonoids as Emerging Anticancer Agents: Current Trends and Recent Advances in Phytotherapy
TLDR
The present chapter summarizes the purported cellular, molecular, and genetic mechanisms of anticancer action of flavonoids, such as apoptosis induction, cell cycle arrest, anti-angiogenesis,Anti-metastasis, and anti-inflammatory and antioxidant aspects. Expand
The potential therapeutic effect of Luteolin against Diethyl nitrosamine induced hepatocellular carcinoma in rats.
TLDR
The efficacy of Luteolin supplementation as an anti-HCC treatment and as a chemo-sensitizer for Cisplatin treatment of HCC in rats are suggested. Expand
Luteolin induces apoptosis in mouse liver cancer cells through ROS mediated pathway: A mechanistic investigation
TLDR
Quantitative real time PCR analysis results showed that luteolin significantly up-regulated the expression of both intrinsic and extrinsic caspases as well as executioner caspase, which clearly showed the details mechanistic pathway by which lutenolin is inducing apoptosis in HepG2. Expand

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TLDR
The apoptotic induction and cell cycle arrest function of luteolin on the liver cancer cells and the related mechanism may be through arresting cell cycle at phase G1/S, enhancing Bax level, reducing anti-apoptotic protein Bcl-2 level, resulting in activating caspase-3 enzyme and decrease of mitochondrial membrane potential, and finally leading to cell apoptosis. Expand
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