Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.

  • Ye Yin, Lu Gao, +4 authors Jie Li
  • Published 2017 in
    Biochemical and biophysical research…

Abstract

In this study, we report that daily administration of luteolin for 8 weeks improved hepatic steatosis by repressing hepatic TG accumulation and increasing glycogen storage. Luteolin inhibited hepatic de novo lipid synthesis by regulating the LXR-SREBP-1c signaling pathway, which is over-activated in the livers of db/db mice. Further in vitro studies… (More)
DOI: 10.1016/j.bbrc.2016.11.101

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@article{Yin2017LuteolinIN, title={Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.}, author={Ye Yin and Lu Gao and Haiyan Lin and Yue Wu and Xiao Han and Yunxia Zhu and Jie Li}, journal={Biochemical and biophysical research communications}, year={2017}, volume={482 4}, pages={720-726} }