Luteolin Attenuation of Azoxymethane-Induced Mitochondiral Enzyme Alterations in Balb/c Mice

Abstract

Colon cancer (CRC) is a serious health problem causes increased mortality every year in worldwide. Highest intake of alcohol, smoking, high fat diets are considered as an etiological factor for the development of CRC. It has three distinct stages including initiation, promotion and progression stages. Multiple signaling alterations were undergoing each stages of the CRC. Therapeutic drugs are designed to target the pathways which is deregulated during cancer will be opt way to deal CRC (Pandurangan, 2013). In general, Natural and synthetic compounds act as crucial chemopreventive agents by modulating oncogenic signals during colon cancer (Sriram et al., 2008; Kumar et al., 2012; Shafie et al., 2013). Mitochondria are the cellular organelles that provide ATP for metabolism and help to maintain calcium homeostasis in the cell. Damage that compromises key functions may adversely affect continued existence of an organism. Although the mitochondrial electron transport chain is a very efficient system, the very nature of the alternating one-electron oxidation-reduction reactions it catalysis (generating a constantly discontinuous series of ‘caged’ radicals) predispose each electron carrier to side reactions with molecular oxygen (Hagen et al., 1998). Reactive oxygen species (ROS) may lead to irreversible damage to mitochondrial DNA, proteins, membrane lipids, resulting in mitochondrial dysfunction and finally cell death (Dalton et al., 1999). Some chemical carcinogen

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Cite this paper

@inproceedings{Pandurangan2013LuteolinAO, title={Luteolin Attenuation of Azoxymethane-Induced Mitochondiral Enzyme Alterations in Balb/c Mice}, author={Ashok Kumar Pandurangan and Suresh Kumar and Ananda Sadagopan and Prakash Dharmalingam and Sudhandiran Ganapasam}, year={2013} }