Luteinizing hormone-releasing hormone-binding sites in the rat thymus: characteristics and biological function.

@article{Marchetti1989LuteinizingHH,
  title={Luteinizing hormone-releasing hormone-binding sites in the rat thymus: characteristics and biological function.},
  author={Bianca Marchetti and V Guarcello and Maria Concetta Morale and Giovanni Bartoloni and Zelinda Farinella and Santa Cordaro and Umberto Scapagnini},
  journal={Endocrinology},
  year={1989},
  volume={125 2},
  pages={1025-36}
}
The present study was designed to explore the effects of LHRH and its agonists on immune system function. As a first step, to identify a putative site of action, the very potent and stable LHRH agonist (LHRH-A), [D-Ser(TBU6)] des-Gly10-LHRH ethylamide (buserelin), was used as an iodinated ligand to characterize LHRH receptors in a membrane preparation of rat thymus, a key organ of the immune system. The effects of LHRH and LHRH-A were then investigated on the proliferative capacity of rat… CONTINUE READING
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