Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.

@article{Keri2000LuteinizingHI,
  title={Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.},
  author={R. A. Keri and Kristen L. Lozada and Fadi W. Abdul-Karim and Joseph H. Nadeau and John H. Nilson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 1},
  pages={383-7}
}
The use of fertility drugs has continued to grow since their introduction in the 1960s. Accompanying this increase has been the speculation that repetitive use of these drugs can cause ovarian tumors or cancer. We recently reported that transgenic mice with chronically elevated luteinizing hormone (LH), an analog of which is commonly used in fertility regimens, develop granulosa cell (GC) tumors. In this report we show that LH induction of these tumors is highly dependent on genetic background… CONTINUE READING