Luteinizing hormone-dependent gene regulation in Leydig cells may be mediated by CCAAT/enhancer-binding protein-beta.

@article{Nalbant1998LuteinizingHG,
  title={Luteinizing hormone-dependent gene regulation in Leydig cells may be mediated by CCAAT/enhancer-binding protein-beta.},
  author={Demet Nalbant and Simon C. Williams and Douglas M. Stocco and Shafiq A Khan},
  journal={Endocrinology},
  year={1998},
  volume={139 1},
  pages={
          272-9
        }
}
Leydig cells are located in the interstitium of the testis and function as the primary site for testosterone biosynthesis. Leydig cell development and steroidogenic function are dependent upon pituitary-derived LH. Circulating LH levels in prepubertal mammals are low but rise sharply during puberty, inducing terminal differentiation of immature Leydig cells into adult Leydig cells. The molecular mechanisms involved in LH action on differentiation specific gene expression and initiation of… CONTINUE READING

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