Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro.

@article{Feelders2003LuteinizingH,
  title={Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro.},
  author={R A Richard Feelders and Steven W. J. Lamberts and Leo J. Hofland and Peter M. van Koetsveld and Miriam Verhoef-Post and Axel P. N. Themmen and Frank H. de Jong and H Jaap Bonjer and Adrian J. L. Clark and Aart J van der Lely and Wouter W de Herder},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 1},
  pages={230-7}
}
In a substantial part of adrenal adenomas and hyperplasias from patients with Cushing's syndrome, cortisol production is controlled by the expression of aberrant hormone receptors on adrenocortical cells. We present in vivo and in vitro data of two patients with a LH-responsive Cushing's syndrome based on ACTH-independent bilateral adrenal hyperplasia. Patients 1 and 2 are women who presented with Cushing's syndrome and bilateral adrenal hyperplasia. Endocrine testing demonstrated absence of… CONTINUE READING